Measurement and modeling of thermodynamic properties for the. Polymer processing using supercritical fluids sciencedirect. Supercritical fluids are well established as a processing solvent in various polymer applications such as polymer modification, formation of polymer composites, polymer blending, microcellular foaming, particle production and polymerization. The sce technology has been successfully applied at industrial scale for the. Recently, supercritical fluids have emerged as more sustainable alternatives for the organic solvents often used in polymer processes. University of groningen polymer melt micronisation using. Enabling extensions of topdown processes using supercritical fluids the fabrication of microelectronic devices using silicon wafer processing is cur. Watkins polymer science and engineering department, university of massachusettsamherst, amherst, massachusetts 01003 received july 22, 2009 contents 1.
The analysis of polymer additives using supercritical. Read principles of polymer processing online, read in mobile or kindle. Co 2 is a good solvent for many nonpolar and some polar molecules with low molecular weights but it is a very poor solvent for most high molecular weight polymers at normal operating conditions. The dyeing of polypropylene fibers in supercritical fluid yu liqiu, zhang shufen. The extraction can be selective to some extent by controlling the density of the medium, and the extracted.
Conventional devolatilization techniques for the purification of polymers have limited effectiveness. Pdf supercritical fluids processing of polymers for. A supercritical fluids extraction process for the production. Supercritical fluid applications in the pharmaceutical industry many promising new pharmaceutical applications are currently under development for supercritical fluid technology. Surface morphology and drug loading characterization of 3d. Supercritical and nearcritical co2 in green chem ical synthesis and processing. The ability of supercritical carbon dioxide to swell and plasticize polymers is crucial to the. Elevated pressure co2 is known to swell and plasticize glassy polymers. Processing of medical polymers with supercritical fluids.
Polymer processing with supercritical fluids goodship. Supercritical fluid applications in the pharmaceutical. Supercritical fluids also make appealing solvents due to the opportunities for tuning of solvent properties through changes in temperature and pressure. A wide range of polymers can be a processed to unique technical and economic advantage with supercritical fluids, especially when wiped film evaporation wfe, molecular distillation, and liquid solvent extraction cannot achieve the requisite properties for increasingly demanding in. A supercritical fluid scf is a substance that is compressed beyond the critical pressure and heated above the critical temperature see figure. This process uses supercritcal fluids to increase the bioavailability of active principles.
The formation of polymer drug microparticles and microspheres, the production of simple or loaded membranes and the formation of. Supercritical fluid processing of polymers in situ spectroscopy of co2induced plasticization of glassy polymers we have applied in situ ftir, atrir and photoacoustic spectroscopy to identify for the first time specific molecular interactions between co2 and polymers that may be responsible for the plasticization of glassy polymers. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Supercritical fluids materials and natural products processing.
This cited by count includes citations to the following articles in scholar. Dear colleagues, we introduce the promising applications of supercritical fluid technology to polymer relating fields. Palladium nanoparticle incorporation in conjugated microporous polymers by supercritical fluid processing. Guide for authors the journal of supercritical fluids. At these conditions, the vapour and liquid phases become. Processing of polymers with supercritical fluids by sacide alsoy and j. Supercritical fluids in biomedical and tissue engineering. Enhancement of polyvinyl ester solubility in supercritical.
Polymer processing using supercritical fluids core reader. Supercritical fluids act as a new media for the generation of novel crystalline forms of apis active pharmaceutical ingredients named as pharmaceutical cocrystals. Supercritical fluid extraction sfe plants are operating at throughputs of 100,000,000 lbsyr or more in the foods industry. Principles of polymer processing also available in format docx and mobi. Download principles of polymer processing ebook for free in pdf and epub format. Elsevier the journal of supercritical fluids template. The journal of supercritical fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. In the field of regenerative medicine scaffolds, supercritical fluids scfs were initially utilised to create microporous biodegradable polymeric foams.
A critical analysis is presented of the supercritical. This is the first book emphasizing the potential of supercritical carbon dioxide for polymer processes from an engineering point of view. Conversion of biomass main goal of scw usage scw gasification of biomass used with wet biomass 80% water weight reaction occurs by forcing biomass slurry into. Principles of polymer processing download pdfepub ebook. Processing of polymers with supercritical fluids alsoy. Coffee and tea are decaffeinated via supercritical fluid extraction and most major brewers in the us and europe use flavors that are extracted from hops with supercritical fluids. Polymer production and processing using supercritical carbon dioxide. Supercritical carbon dioxide as a green solvent for processing polymers 3 extraction applications and in polymer synthesis 14. In addition, the improved product quality is also an important concern for its selection 14.
Production of micronic particles of biocompatible polymer using supercritical. Methods for modelling of solubilities of compounds and influence of cosolvent in supercritical fluid 26 4. More detailed historical overviews are given by jessop and leitner 12 and by mchugh and krukonis 40. The consequent reduction of surface tension and viscosity allows the production of micrometric or nanometric particles of controlled size and distribution at a production rate up to one. Supercritical co 2 at 20 mpa was used as the blowing agent and the specimens were foamed in a hot press to ensure flatness for further processing and characterization. Introduction to supercritical fluids, volume 4 1st edition. Extraction and precipitation particle coating using supercritical. As detailed later, deposition reactions within polymer templates dilated in co 2 provide direct access to devicequality nanostructured silicate, titania, and carbon films.
Solubility of supercritical co2 in polystyrene during foam. Application of supercritical and subcritical fluids in food processing. Supercritical fluids for the fabrication of semiconductor devices. Processing at lower temperatures can also be expected to be similar to general molding processes and may be useful from the viewpoint of green chemistry. A variety of polymer processing techniques have been developed and include solvent casting and particles leaching, compression moulding and particle leaching, thermally induced phase separation, rapid prototyping, among others. Extrusion process is one of the most important innovations of the 20 th century applied in many industries. The technologies required to use supercritical fluids in polymer processing operation in addition to the effects of supercritical fluids on both the polymer material and the final product are outlined. The chromatogram of the 4 polymer additive standards separated using a. Pdf processing of polymers using supercritical fluids.
Sorption studies showed that at 20 mpa, pei can absorb about 10% co 2 by weight and that a 1mm thick specimen can reach an equilibrium concentration in approximately 100 h at 45. Polymer concentration supercritical fluid lower critical solution. Very recently, critical pharmaceuticles united kingdom offers biocompatible and biodegradable polymers synthesized using environment friendly supercritical co 2 for medical and pharmaceutical applications. For example, conditions that give a low viscosity supercritical fluid result in diminished solvent cage effects in freeradical initiator decompositions. Supercritical carbon dioxide as a green solvent for processing polymers 7. Pdf supercritical fluids have a unique and valuable potential for the enhanced processing of many materials. The use of most supercritical sc fluids in industrial processes can replace. In the last decade, there has been an interest developed in the use of supercritical fluids, such as co2, for the formation of polymer foams.
The chamber was connected in the supercritical co 2 foaming setup as shown in fig. In addition to an extruder, a static mixer has been used to form a single phase solution. A twin screw extruder and a twinsingle tandem extruder system 176, 177 have been utilized for experiments on processing poly ethylenepolystyrene blends with scco2. Supercritical fluids scf have recently achieved a widespread attention in the synthesis and processing of thermoplastic polymers. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to. Recently there has been great interest in processing polymers using supercritical carbon dioxide 16,17. The application of supercritical fluid sf processing in pharmaceutical research. Unlike chemical blowing agents cbas added conveniently into the polymer formulation and subsequently produces a gas during polymer processing, the use of supercritical fluid has become very attractive. The use of supercritical carbon dioxide, scco is a gas under atmospheric conditions, it can be used as a processing aid and then easily removed from a polymer through evaporation to obtain the original physical properties of the unplasticized polymer matrix. A supercritical fluid scf is a fluid above its critical. Pdf polymer processing with supercritical fluids researchgate. Home applications the analysis of polymer additives using supercritical fluid chromatography. Unleashing the potential of supercritical fluids for. Comprehensive summaries of uppsala dissertations from the faculty of pharmacy 234.
Palladium nanoparticle incorporation in conjugated microporous polymers by supercritical fluid processing tom hasell, colin d. A supercritical fluid is defined as a substance for which the temperature and. Drug impregnation using supercritical fluids has been largely studied for polymeric materials, but there is limited available research for subsequent impregnation of 3dprinted materials with apis. Supercritical carbon dioxide co 2 as a nontoxic, nonflammable and inexpensive, is applied in many processes, including the extrusion technology. Larry duda 1 introduction the removal of impurities, such as residual solvents, unreacted monomers, catalysts, and sidereaction products from polymers represents an important step in polymer processing. Palladium nanoparticle incorporation in conjugated. Since the physical and mechanical properties of polymers are dependent on their molecular weights, the properties of synthetic polymers are distributed over a wide range. The analysis of polymer additives using supercritical fluid chromatography. Generally, synthetic polymers have a wide distribution in the molecular weights of components. As these fluids never condense at above their critical. A thesis submitted to the university of birmingham for the award of the degree. Supercritical co 2 scco 2 processing has emerged as a promising approach for loading drugs into implants 5,15,16 due to several advantages.
Supercritical fluids and their application to the recycling of highperformance carbon fibre reinforced composite materials. A supercritical fluids extraction process for the production of drug loaded biodegradable microparticles. Polymer modification in supercritical and subcritical fluids. However, there have been limited studies reporting the physical properties of engineering plastics plasticized using supercritical fluids. Zwarts, in het openbaar te verdedigen op vrijdag 2 december 2005 om. A brief history and the advantages of using supercritical fluids are presented first, followed by a discussion on the use of supercritical. Application of supercritical carbon dioxide extrusion in food. Dr michel perrut, lavipharm laboratories usa and separex france d uring the last two decades, industrial applications of supercritical fluids have. Fluid over its critical temperature and pressure, exhibiting good solvent power. Supercritical foaming to obtain drugencapsulated foam approximate 100 mg of drugencapsulated particles were weighted and packed in a 1 cm diameter, custommade cylindrical shaped mold aluminum and loaded in the supercritical foaming chamber. Polymer processing using supercritical fluid based.
Purchase introduction to supercritical fluids, volume 4 1st edition. Scf technology has the ability to swell and plasti. Drug delivery, polymer processing, regenerative medicine, scaffolds, supercritical fluids, tissue engineering. The ability of supercritical carbon dioxide to swell and plasticize polymers is crucial to the impregnation, extraction, and modification of polymeric materials. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Specific interactions between supercritical fluids and polymers lead to many attractive development 12. Supercritical fluids processing of polymers for pharmaceutical and medical applications. Phasebehavior of telechelic polyisobutylene pib in subcritical. Phase behavioral effects on particle formation processes using. Supercritical carbon dioxide one of the supercritical fluids, which can be used, is carbon dioxide co2. Supercritical fluids for the fabrication of semiconductor. Polymer miscibility and kinetics of pressure induced phase. The advantages of supercritical fluid extraction compared with liquid extraction are that it is relatively rapid because of the low viscosities and high diffusivities associated with supercritical fluids. Apart from the alreadycited applications, many new applications of supercritical fluids are now either under commercial development in many areas, sometimes really unexpected. Supercritical fluids have a unique and valuable potential for the enhanced processing of many materials. Supercritical fluids, mainly supercritical co2, have been widely applied in the chemistry and processing of polymers. Supercritical fluids scf supercritical fluid extraction.
Polymer synthesis and processing using supercritical carbon dioxide. This chapter describes the use of supercritical fluids in modern polymer processing operations. Ohshima, the polymer processing society 15th annual meeting, s. Measurement and modeling of thermodynamic properties for. Supercritical fluid polymer interactions phaseequilibrium data for solutions of polystyrenes in normal butane and normal. Unleashing the potential of supercritical fluids for polymer.
The consequent reduction of surface tension and viscosity allows the production of micrometric or nanometric particles of controlled size and distribution at a production rate up to one hundred times that of the traditional process. A new process is proposed that can largely improve classical electrospray espr atomization, thanks to the addition of supercritical co 2 scco 2 to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Material processing using supercritical fluids springerlink. Polymer processing with supercritical fluids goodship, vannessa the use of supercritical fluids scfs in the polymer industry presents an opportunity to create unique products both now and in the future as demand and usage of the technology further develops. Supercritical fluid technology offers a new platform that allows a singlestep generation of particles that are difficult or even impossible to obtain by traditional techniques. The dyeing of polypropylene fibers in supercritical fluid.
Although the solubility of most polymers in co 2 is extremely low, the solubility of co 2 in many polymers is substantial. Supercritical fluid technology has already proven to be feasible for many pharmaceutical applications and is now emerging as an alternative to conventional materials processing methods for the preparation of threedimensional structures and injectable particles suitable to be used in regenerative medicine. Devolatilization with supercritical fluids, however, can enhance impurity removal by increasing the thermodynamic driving force and molecular diffusivity. Polymer processing with supercritical fluids imperial college. Supercritical fluids appear as an interesting alternative to the conventional methods for processing. Extrusion is a technology that is increasingly used for the production of various food products, especially snacks and breakfast cereals. Characterization of engineering plastics plasticized using. Polymers and supercritical fluids applied separations.
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